diff --git a/crane.nix b/crane.nix
index b20f9c6..cc6c625 100644
--- a/crane.nix
+++ b/crane.nix
@@ -52,7 +52,10 @@ let
         };
       };
     };
-    systems = lib.filter (s: s == system || lib.hasInfix "linux" s) supportedSystems;
+    systems = lib.filter (s: s == system || lib.hasInfix "linux" s) supportedSystems
+      # Cross from aarch64-darwin -> x86_64-darwin doesn't work yet
+      # Hopefully the situation will improve with the SDK bumps
+      ++ lib.optional (system == "x86_64-darwin") "aarch64-darwin";
   in builtins.listToAttrs (map makeCrossPlatform systems);
 
   cargoTargets = lib.mapAttrsToList (_: p: p.rustTargetSpec) crossPlatforms;
diff --git a/flake.nix b/flake.nix
index acd68ed..c6261c8 100644
--- a/flake.nix
+++ b/flake.nix
@@ -57,6 +57,82 @@
 
           age
         ];
+
+        # We _can_ cross-compile to multiple systems with one shell :)
+        #
+        # Currently stdenv isn't set up to do that, but we can invoke
+        # the setup mechinary in a sub-shell then compose the results.
+        shellHook = let
+          crossSystems = lib.filter (s: s != pkgs.system) (builtins.attrNames cranePkgs.crossPlatforms);
+        in ''
+          # Returns compiler environment variables for a platform
+          #
+          # getTargetFlags "suffixSalt" "nativeBuildInputs" "buildInputs"
+          getTargetFlags() {
+            # Here we only call the setup-hooks of nativeBuildInputs.
+            #
+            # What's off-limits for us:
+            #
+            # - findInputs
+            # - activatePackage
+            # - Other functions in stdenv setup that depend on the private accumulator variables
+            (
+              suffixSalt="$1"
+              nativeBuildInputs="$2"
+              buildInputs="$3"
+
+              # Offsets for the nativeBuildInput (e.g., gcc)
+              hostOffset=-1
+              targetOffset=0
+
+              # In stdenv, the hooks are first accumulated before being called.
+              # Here we call them immediately
+              addEnvHooks() {
+                local depHostOffset="$1"
+                # For simplicity, we only call the hook on buildInputs
+                for pkg in $buildInputs; do
+                  depTargetOffset=1
+                  $2 $pkg
+                done
+              }
+
+              unset _PATH
+              unset NIX_CFLAGS_COMPILE
+              unset NIX_LDFLAGS
+
+              # For simplicity, we only call the setup-hooks of nativeBuildInputs
+              for nbi in $nativeBuildInputs; do
+                addToSearchPath _PATH "$nbi/bin"
+
+                if [ -e "$nbi/nix-support/setup-hook" ]; then
+                  source "$nbi/nix-support/setup-hook"
+                fi
+              done
+
+              echo "export NIX_CFLAGS_COMPILE_''${suffixSalt}='$NIX_CFLAGS_COMPILE'"
+              echo "export NIX_LDFLAGS_''${suffixSalt}='$NIX_LDFLAGS'"
+              echo "export PATH=$PATH''${_PATH+:$_PATH}"
+            )
+          }
+
+          target_flags=$(mktemp)
+          ${lib.concatMapStrings (system: let
+            crossPlatform = cranePkgs.crossPlatforms.${system};
+          in ''
+            getTargetFlags \
+              "${crossPlatform.cc.suffixSalt}" \
+              "${crossPlatform.cc} ${crossPlatform.cc.bintools}" \
+              "${builtins.concatStringsSep " " (crossPlatform.buildInputs ++ crossPlatform.pkgs.stdenv.defaultBuildInputs)}" >$target_flags
+            . $target_flags
+          '') crossSystems}
+          rm $target_flags
+
+          # Suffix flags for current system as well
+          export NIX_CFLAGS_COMPILE_${pkgs.stdenv.cc.suffixSalt}="$NIX_CFLAGS_COMPILE"
+          export NIX_LDFLAGS_${pkgs.stdenv.cc.suffixSalt}="$NIX_LDFLAGS"
+          unset NIX_CFLAGS_COMPILE
+          unset NIX_LDFLAGS
+        '';
       } // cranePkgs.cargoCrossEnvs);
       keygen = pkgs.mkShellNoCC {
         packages = with pkgs; [